Review



polyclonal r d systems af2535 ab 2063012 foxp1  (R&D Systems)


Bioz Verified Symbol R&D Systems is a verified supplier
Bioz Manufacturer Symbol R&D Systems manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 96

    Structured Review

    R&D Systems polyclonal r d systems af2535 ab 2063012 foxp1
    Polyclonal R D Systems Af2535 Ab 2063012 Foxp1, supplied by R&D Systems, used in various techniques. Bioz Stars score: 96/100, based on 422 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mouse+foxp1/Mouse+MMR%2FCD206+Antibody/pmc11018859__41467_2024_47185_MOESM2_ESM-29-45-46
    Average 96 stars, based on 422 article reviews
    polyclonal r d systems af2535 ab 2063012 foxp1 - by Bioz Stars, 2026-09
    96/100 stars

    Images

    Related Articles

    Staining:

    Article Title: Cell cycle inhibitors protect motor neurons in an organoid model of Spinal Muscular Atrophy
    Article Snippet: Primary antibodies were diluted in blocking buffer and incubated overnight at 4 °C.antibodies were diluted in blocking buffer and incubated overnight at 4 °C. ... The following primary antibodies (and their respective dilutions) were used: rabbit SOX1 (1:1000) (Abcam, ab87775), mouse Nestin (1:1000) (Abcam, ab22035), rabbit ISL1 (1:1500) (Abcam, ab109517), rabbit cleaved Caspase-3 (1:1000) (Cell Signaling Technology, #9661), mouse Ki67 (1:1500) (Cell Signaling Technology, #9449), mouse SMI-32 (1:1000) (Calbiochem, NE-1023), mouse SMN (1:400) (BD Pharmingen, 610647), rabbit Ki67 (1:250) (Abcam, ab16667), mouse TUJ1 (1:2000) (Biolegend, #801202), goat SOX10 (1:100) (Santa Cruz Biotechnologies, sc-17342), rabbit HOXB4 (1:200) (Abcam, ab133521), rabbit HOXC8 (1:200) (Abcam, ab86236), rabbit Calbindin (1:1000) (Abcam, ab11426), mouse FoxP1 (1:100) (R&D Systems, MAB45341), and sheep Chx10 (1:200) (Abcam, ab16141).. The cells were washed thrice in PBS.The cells were washed thrice in PBS.

    Real-time Polymerase Chain Reaction:

    Article Title: Cell cycle inhibitors protect motor neurons in an organoid model of Spinal Muscular Atrophy
    Article Snippet: Primary antibodies were diluted in blocking buffer and incubated overnight at 4 °C.antibodies were diluted in blocking buffer and incubated overnight at 4 °C. ... The following primary antibodies (and their respective dilutions) were used: rabbit SOX1 (1:1000) (Abcam, ab87775), mouse Nestin (1:1000) (Abcam, ab22035), rabbit ISL1 (1:1500) (Abcam, ab109517), rabbit cleaved Caspase-3 (1:1000) (Cell Signaling Technology, #9661), mouse Ki67 (1:1500) (Cell Signaling Technology, #9449), mouse SMI-32 (1:1000) (Calbiochem, NE-1023), mouse SMN (1:400) (BD Pharmingen, 610647), rabbit Ki67 (1:250) (Abcam, ab16667), mouse TUJ1 (1:2000) (Biolegend, #801202), goat SOX10 (1:100) (Santa Cruz Biotechnologies, sc-17342), rabbit HOXB4 (1:200) (Abcam, ab133521), rabbit HOXC8 (1:200) (Abcam, ab86236), rabbit Calbindin (1:1000) (Abcam, ab11426), mouse FoxP1 (1:100) (R&D Systems, MAB45341), and sheep Chx10 (1:200) (Abcam, ab16141).. The cells were washed thrice in PBS.The cells were washed thrice in PBS.

    Generated:

    Article Title: Cell cycle inhibitors protect motor neurons in an organoid model of Spinal Muscular Atrophy
    Article Snippet: Primary antibodies were diluted in blocking buffer and incubated overnight at 4 °C.antibodies were diluted in blocking buffer and incubated overnight at 4 °C. ... The following primary antibodies (and their respective dilutions) were used: rabbit SOX1 (1:1000) (Abcam, ab87775), mouse Nestin (1:1000) (Abcam, ab22035), rabbit ISL1 (1:1500) (Abcam, ab109517), rabbit cleaved Caspase-3 (1:1000) (Cell Signaling Technology, #9661), mouse Ki67 (1:1500) (Cell Signaling Technology, #9449), mouse SMI-32 (1:1000) (Calbiochem, NE-1023), mouse SMN (1:400) (BD Pharmingen, 610647), rabbit Ki67 (1:250) (Abcam, ab16667), mouse TUJ1 (1:2000) (Biolegend, #801202), goat SOX10 (1:100) (Santa Cruz Biotechnologies, sc-17342), rabbit HOXB4 (1:200) (Abcam, ab133521), rabbit HOXC8 (1:200) (Abcam, ab86236), rabbit Calbindin (1:1000) (Abcam, ab11426), mouse FoxP1 (1:100) (R&D Systems, MAB45341), and sheep Chx10 (1:200) (Abcam, ab16141).. The cells were washed thrice in PBS.The cells were washed thrice in PBS.



    Similar Products

    93
    Santa Cruz Biotechnology mouse anti foxp1
    Mouse Anti Foxp1, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mouse+foxp1/FOXP1+Antibody/pmc12934524-0-0-3
    Average 93 stars, based on 1 article reviews
    mouse anti foxp1 - by Bioz Stars, 2026-09
    93/100 stars
      Buy from Supplier

    93
    Santa Cruz Biotechnology mouse anti foxp1 santa cruz
    Mouse Anti Foxp1 Santa Cruz, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mouse+foxp1/FOXP1+Antibody/pm41733412-90-0-2
    Average 93 stars, based on 1 article reviews
    mouse anti foxp1 santa cruz - by Bioz Stars, 2026-09
    93/100 stars
      Buy from Supplier

    91
    Bio-Rad mouse igg2a
    Mouse Igg2a, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mouse+foxp1/Mouse+anti+FOXP1/pmc11993912-574-2-5
    Average 91 stars, based on 1 article reviews
    mouse igg2a - by Bioz Stars, 2026-09
    91/100 stars
      Buy from Supplier

    90
    Jackson Laboratory mouse: stock foxp1 tm1.1pwt /j
    (A) Schematic showing the genotypes used in this study. D1-cre-mediated loss of <t>Foxp1</t> (Foxp1 D1 ; purple), Foxp2 (Foxp2 D1 ; cyan), or both (Foxp1/2 D1 ; gold), as well as Cre-negative controls (gray). (B–E) Representative images of immunohistochemistry for Foxp1, Foxp2, and Hoechst in control (B), Foxp1 D1 (C), Foxp2 D1 (D), and Foxp1/2 D1 (E). All images from P56 mice. Scale bars represent 750 μM. 20× magnification.
    Mouse: Stock Foxp1 Tm1.1pwt /J, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mouse+foxp1/foxp1+flox+flox+mice/pmc11234887-52-0-6
    Average 90 stars, based on 1 article reviews
    mouse: stock foxp1 tm1.1pwt /j - by Bioz Stars, 2026-09
    90/100 stars
      Buy from Supplier

    95
    Cell Signaling Technology Inc mouse anti gfp
    (A) Schematic showing the genotypes used in this study. D1-cre-mediated loss of <t>Foxp1</t> (Foxp1 D1 ; purple), Foxp2 (Foxp2 D1 ; cyan), or both (Foxp1/2 D1 ; gold), as well as Cre-negative controls (gray). (B–E) Representative images of immunohistochemistry for Foxp1, Foxp2, and Hoechst in control (B), Foxp1 D1 (C), Foxp2 D1 (D), and Foxp1/2 D1 (E). All images from P56 mice. Scale bars represent 750 μM. 20× magnification.
    Mouse Anti Gfp, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mouse+foxp1/FoxP1+Antibody/pm38936368-364-10-18
    Average 95 stars, based on 1 article reviews
    mouse anti gfp - by Bioz Stars, 2026-09
    95/100 stars
      Buy from Supplier

    96
    R&D Systems polyclonal r d systems af2535 ab 2063012 foxp1
    (A) Schematic showing the genotypes used in this study. D1-cre-mediated loss of <t>Foxp1</t> (Foxp1 D1 ; purple), Foxp2 (Foxp2 D1 ; cyan), or both (Foxp1/2 D1 ; gold), as well as Cre-negative controls (gray). (B–E) Representative images of immunohistochemistry for Foxp1, Foxp2, and Hoechst in control (B), Foxp1 D1 (C), Foxp2 D1 (D), and Foxp1/2 D1 (E). All images from P56 mice. Scale bars represent 750 μM. 20× magnification.
    Polyclonal R D Systems Af2535 Ab 2063012 Foxp1, supplied by R&D Systems, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mouse+foxp1/Mouse+MMR%2FCD206+Antibody/pmc11018859__41467_2024_47185_MOESM2_ESM-29-45-46
    Average 96 stars, based on 1 article reviews
    polyclonal r d systems af2535 ab 2063012 foxp1 - by Bioz Stars, 2026-09
    96/100 stars
      Buy from Supplier

    93
    Santa Cruz Biotechnology mouse antifoxp1
    (A) Schematic showing the genotypes used in this study. D1-cre-mediated loss of <t>Foxp1</t> (Foxp1 D1 ; purple), Foxp2 (Foxp2 D1 ; cyan), or both (Foxp1/2 D1 ; gold), as well as Cre-negative controls (gray). (B–E) Representative images of immunohistochemistry for Foxp1, Foxp2, and Hoechst in control (B), Foxp1 D1 (C), Foxp2 D1 (D), and Foxp1/2 D1 (E). All images from P56 mice. Scale bars represent 750 μM. 20× magnification.
    Mouse Antifoxp1, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mouse+foxp1/FOXP1+Antibody/pm36646976-70-18-21
    Average 93 stars, based on 1 article reviews
    mouse antifoxp1 - by Bioz Stars, 2026-09
    93/100 stars
      Buy from Supplier

    Image Search Results


    (A) Schematic showing the genotypes used in this study. D1-cre-mediated loss of Foxp1 (Foxp1 D1 ; purple), Foxp2 (Foxp2 D1 ; cyan), or both (Foxp1/2 D1 ; gold), as well as Cre-negative controls (gray). (B–E) Representative images of immunohistochemistry for Foxp1, Foxp2, and Hoechst in control (B), Foxp1 D1 (C), Foxp2 D1 (D), and Foxp1/2 D1 (E). All images from P56 mice. Scale bars represent 750 μM. 20× magnification.

    Journal: Cell reports

    Article Title: Compensation between FOXP transcription factors maintains proper striatal function

    doi: 10.1016/j.celrep.2024.114257

    Figure Lengend Snippet: (A) Schematic showing the genotypes used in this study. D1-cre-mediated loss of Foxp1 (Foxp1 D1 ; purple), Foxp2 (Foxp2 D1 ; cyan), or both (Foxp1/2 D1 ; gold), as well as Cre-negative controls (gray). (B–E) Representative images of immunohistochemistry for Foxp1, Foxp2, and Hoechst in control (B), Foxp1 D1 (C), Foxp2 D1 (D), and Foxp1/2 D1 (E). All images from P56 mice. Scale bars represent 750 μM. 20× magnification.

    Article Snippet: Mouse: STOCK Foxp1 tm1.1Pwt /J , Jackson Laboratory , Strain#: 017699; RRID: IMSR_JAX:017699.

    Techniques: Immunohistochemistry, Control

    (A) UMAP of the neuron-only subset with colors indicating the different annotated cell types. D1-SPNs were used for DEG analysis. Genes were called differentially expressed if they had an adjusted p value <0.05 and logFC > |0.25|. (B) Semi-scaled Venn diagram showing number of unique and overlapping DEGs in each knockout condition in the D1-SPNs. Overlap of DEGs between conditions was assessed by a Fisher’s exact test enrichment. (C) Bar plots showing the number of up- and downregulated genes in each knockout condition. (D) Bubble chart showing enrichment of DEGs from each knockout condition. The −log 10 ( p value) for each enrichment is also indicated. ASD, SFARI ASD-risk genes; ASD 1–3, SFARI ASD-risk genes with scores of 1–3; FMRP, fragile X syndrome; ID, intellectual disability. (E–G) GO analysis of (E) Foxp1 D1 , (F) Foxp2 D1 , and (G) Foxp1/2 D1 DEGs reveals enrichment for terms associated with electrophysiological properties and synaptic properties.

    Journal: Cell reports

    Article Title: Compensation between FOXP transcription factors maintains proper striatal function

    doi: 10.1016/j.celrep.2024.114257

    Figure Lengend Snippet: (A) UMAP of the neuron-only subset with colors indicating the different annotated cell types. D1-SPNs were used for DEG analysis. Genes were called differentially expressed if they had an adjusted p value <0.05 and logFC > |0.25|. (B) Semi-scaled Venn diagram showing number of unique and overlapping DEGs in each knockout condition in the D1-SPNs. Overlap of DEGs between conditions was assessed by a Fisher’s exact test enrichment. (C) Bar plots showing the number of up- and downregulated genes in each knockout condition. (D) Bubble chart showing enrichment of DEGs from each knockout condition. The −log 10 ( p value) for each enrichment is also indicated. ASD, SFARI ASD-risk genes; ASD 1–3, SFARI ASD-risk genes with scores of 1–3; FMRP, fragile X syndrome; ID, intellectual disability. (E–G) GO analysis of (E) Foxp1 D1 , (F) Foxp2 D1 , and (G) Foxp1/2 D1 DEGs reveals enrichment for terms associated with electrophysiological properties and synaptic properties.

    Article Snippet: Mouse: STOCK Foxp1 tm1.1Pwt /J , Jackson Laboratory , Strain#: 017699; RRID: IMSR_JAX:017699.

    Techniques: Knock-Out

    (A) Ntn1 showed a downregulated expression in Foxp1 D1 D1-SPNs. (B) This decrease is not in Foxp2 D1 D1-SPNs. (C) Regions of interest (ROI) used to identify D1 SPNs (based on Tac1 expression) and puncta for Ntn1 transcripts were counted in each ROI from each each image. (D) Cdk7 also showed a reduced expression in Foxp1 D1 D1-SPNs. (E) There was a trend toward a decrease in Foxp2 D1 D1-SPNs ( p = 0.08). (F) ROIs used to quantify puncta for Cdk7 in a similar fashion to Ntn1 . Sample size ( n ) is the representative of the number of cells counted from each genotype. n = 482 cells, three mice (control, Ntn1 ); 403 cells, two mice ( Foxp1 D1 , Ntn1 ); 392 cells, two mice ( Foxp2 D1 , Ntn1 ); 536 cells, three mice (control, Cdk7 ); 636 cells, three mice ( Foxp1 D1 , Cdk7 ); and 626 cells, three mice ( Foxp2 D1 , Cdk7 ). Scale bars represent 50 mM and images were taken at 20× magnification. A Mann-Whitney’s U test was performed to assess statistical significance, * p < 0.05, **** p < 0.0001. All graphs are displayed as mean ± SEM.

    Journal: Cell reports

    Article Title: Compensation between FOXP transcription factors maintains proper striatal function

    doi: 10.1016/j.celrep.2024.114257

    Figure Lengend Snippet: (A) Ntn1 showed a downregulated expression in Foxp1 D1 D1-SPNs. (B) This decrease is not in Foxp2 D1 D1-SPNs. (C) Regions of interest (ROI) used to identify D1 SPNs (based on Tac1 expression) and puncta for Ntn1 transcripts were counted in each ROI from each each image. (D) Cdk7 also showed a reduced expression in Foxp1 D1 D1-SPNs. (E) There was a trend toward a decrease in Foxp2 D1 D1-SPNs ( p = 0.08). (F) ROIs used to quantify puncta for Cdk7 in a similar fashion to Ntn1 . Sample size ( n ) is the representative of the number of cells counted from each genotype. n = 482 cells, three mice (control, Ntn1 ); 403 cells, two mice ( Foxp1 D1 , Ntn1 ); 392 cells, two mice ( Foxp2 D1 , Ntn1 ); 536 cells, three mice (control, Cdk7 ); 636 cells, three mice ( Foxp1 D1 , Cdk7 ); and 626 cells, three mice ( Foxp2 D1 , Cdk7 ). Scale bars represent 50 mM and images were taken at 20× magnification. A Mann-Whitney’s U test was performed to assess statistical significance, * p < 0.05, **** p < 0.0001. All graphs are displayed as mean ± SEM.

    Article Snippet: Mouse: STOCK Foxp1 tm1.1Pwt /J , Jackson Laboratory , Strain#: 017699; RRID: IMSR_JAX:017699.

    Techniques: Expressing, Control

    (A) UMAP showing annotated cell types in snATAC-seq analysis. D1-SPNs were used for further DAR analysis. A region was called differentially accessible if it hadan adjusted p value <0.05 and a logFC > |0.1375|. (B) Semi-scaled Venn diagram showing the number of unique and overlapping DARs within each condition. Overlap of DARs between conditions was assessed by a Fisher’s exact test. (C) Venn diagrams showing the overlap between DEGs and DARs in Foxp1/2 D1 D1-SPNs. Overlap was assessed for significance by fold enrichment. (D) Bar plot showing the number of more open or more closed regions in each knockout condition. Motifs enriched in the DARs of each knockout were identified. (E) Semi-scaled Venn diagram showing the number of unique and overlapping motifs in each genotype. The significance of overlap of motifs was also assessedby a Fisher’s exact test. (F) Bar plot showing the number of motifs enriched within more open or more closed chromatin regions in each knockout condition. FOX motifs (GTAAACA) arehighlighted to indicate enrichment associated with more open regions. (G) Trackfile for Pde1c with the differentially accessible region highlighted.

    Journal: Cell reports

    Article Title: Compensation between FOXP transcription factors maintains proper striatal function

    doi: 10.1016/j.celrep.2024.114257

    Figure Lengend Snippet: (A) UMAP showing annotated cell types in snATAC-seq analysis. D1-SPNs were used for further DAR analysis. A region was called differentially accessible if it hadan adjusted p value <0.05 and a logFC > |0.1375|. (B) Semi-scaled Venn diagram showing the number of unique and overlapping DARs within each condition. Overlap of DARs between conditions was assessed by a Fisher’s exact test. (C) Venn diagrams showing the overlap between DEGs and DARs in Foxp1/2 D1 D1-SPNs. Overlap was assessed for significance by fold enrichment. (D) Bar plot showing the number of more open or more closed regions in each knockout condition. Motifs enriched in the DARs of each knockout were identified. (E) Semi-scaled Venn diagram showing the number of unique and overlapping motifs in each genotype. The significance of overlap of motifs was also assessedby a Fisher’s exact test. (F) Bar plot showing the number of motifs enriched within more open or more closed chromatin regions in each knockout condition. FOX motifs (GTAAACA) arehighlighted to indicate enrichment associated with more open regions. (G) Trackfile for Pde1c with the differentially accessible region highlighted.

    Article Snippet: Mouse: STOCK Foxp1 tm1.1Pwt /J , Jackson Laboratory , Strain#: 017699; RRID: IMSR_JAX:017699.

    Techniques: Knock-Out

    (A) Number of action potentials recorded undercurrent-clamp conditions. (B) Input resistance recorded from the same cells inthe same conditions. (C) Contribution of K Leak channels was determined by finding the difference in current density plots. Values recorded in presence of cesium (see ) were subtracted from those recorded in its absence (see ) with no significant differences observed. (D) Schematic showing pAAV-hSYN-Foxp1-T2A-eGFP construct injected at P1. Dual presence of tdTomato and GFP was used to identify which neurons expressed the FOXP1 construct. (E and F) (E) Current-clamp recordings to record number of action potentials and (F) input resistance. Repeated-measures two-way ANOVA with Holm-Sidak’s post hoc test; only significant differences between knockouts and controls are shown. * p < 0.05 (A and B) n = 56 (control), 32 (Foxp1 D1 ), 40 (Foxp2 D1 ), and 41 (Foxp1/2 D1 ). (C) n = 61, 43, 38, and 41. (E and F) n = 44 (control with control virus), 34 (Foxp1/2 D1 with control virus), 32 (Foxp1/2 D1 with FOXP1 construct), and 19 (control with FOXP1 construct). All graphs are displayed as mean ± SEM.

    Journal: Cell reports

    Article Title: Compensation between FOXP transcription factors maintains proper striatal function

    doi: 10.1016/j.celrep.2024.114257

    Figure Lengend Snippet: (A) Number of action potentials recorded undercurrent-clamp conditions. (B) Input resistance recorded from the same cells inthe same conditions. (C) Contribution of K Leak channels was determined by finding the difference in current density plots. Values recorded in presence of cesium (see ) were subtracted from those recorded in its absence (see ) with no significant differences observed. (D) Schematic showing pAAV-hSYN-Foxp1-T2A-eGFP construct injected at P1. Dual presence of tdTomato and GFP was used to identify which neurons expressed the FOXP1 construct. (E and F) (E) Current-clamp recordings to record number of action potentials and (F) input resistance. Repeated-measures two-way ANOVA with Holm-Sidak’s post hoc test; only significant differences between knockouts and controls are shown. * p < 0.05 (A and B) n = 56 (control), 32 (Foxp1 D1 ), 40 (Foxp2 D1 ), and 41 (Foxp1/2 D1 ). (C) n = 61, 43, 38, and 41. (E and F) n = 44 (control with control virus), 34 (Foxp1/2 D1 with control virus), 32 (Foxp1/2 D1 with FOXP1 construct), and 19 (control with FOXP1 construct). All graphs are displayed as mean ± SEM.

    Article Snippet: Mouse: STOCK Foxp1 tm1.1Pwt /J , Jackson Laboratory , Strain#: 017699; RRID: IMSR_JAX:017699.

    Techniques: Construct, Injection, Control, Virus

    (A) UMAP of the neuron-only subset with colors indicating the cell types. D1-SPNs were used for further DEG analysis. Genes were called differentially expressed if they had an adjusted p value <0.05 and logFC > |0.25|. (B) Semi-scaled Venn diagram showing number of unique and overlapping DEGs in each knockout condition in the D1-SPNs. Overlap of DEGs between conditions was assessed by a Fisher’s exact test. (C) Bar plots showing the number of up- and downregulated genes in each knockout condition. (D) Bubble chart showing enrichment of DEGs from each knockout condition. The −log 10 ( p value) for each enrichment is indicated. ASD, SFARI ASD-risk genes; ASD 1–3, SFARI ASD-risk genes with scores of 1–3; FMRP, fragile X syndrome; ID, intellectual disability. (E–G) Gene Ontology (GO) analysis of (E) Foxp1 D1 , (F) Foxp2 D1 , and (G) Foxp1/2 D1 DEGs reveals enrichment for terms associated with electrophysiological properties and synaptic properties.

    Journal: Cell reports

    Article Title: Compensation between FOXP transcription factors maintains proper striatal function

    doi: 10.1016/j.celrep.2024.114257

    Figure Lengend Snippet: (A) UMAP of the neuron-only subset with colors indicating the cell types. D1-SPNs were used for further DEG analysis. Genes were called differentially expressed if they had an adjusted p value <0.05 and logFC > |0.25|. (B) Semi-scaled Venn diagram showing number of unique and overlapping DEGs in each knockout condition in the D1-SPNs. Overlap of DEGs between conditions was assessed by a Fisher’s exact test. (C) Bar plots showing the number of up- and downregulated genes in each knockout condition. (D) Bubble chart showing enrichment of DEGs from each knockout condition. The −log 10 ( p value) for each enrichment is indicated. ASD, SFARI ASD-risk genes; ASD 1–3, SFARI ASD-risk genes with scores of 1–3; FMRP, fragile X syndrome; ID, intellectual disability. (E–G) Gene Ontology (GO) analysis of (E) Foxp1 D1 , (F) Foxp2 D1 , and (G) Foxp1/2 D1 DEGs reveals enrichment for terms associated with electrophysiological properties and synaptic properties.

    Article Snippet: Mouse: STOCK Foxp1 tm1.1Pwt /J , Jackson Laboratory , Strain#: 017699; RRID: IMSR_JAX:017699.

    Techniques: Knock-Out

    (A) Foxp1/2 D1 mice show motor learning deficit as assessed by latency to fall using the rotarod paradigm. (B) Nest-building quality was assessed after single housing for 24 h with Foxp1 D1 showing impairment, and this is amplified in Foxp1/2 D1 . (C and D) AAV-mediated re-expression of Foxp1 restored measures to baseline in rotarod (C) and nest building (D). (A and B) Behavior performed in control, Foxp1 D1 , Foxp2 D1 , and Foxp1/2 D1 . (C and D) Performed in control or Foxp1/2 D1 mice with either control AAV9-hSYN1-eGFP or pAAV-hSYN-Foxp1-T2A-eGFP construct. (A–D) Two-way ANOVA with Tukey’s post hoc analysis used to determine significance. * p < 0.05, ** p < 0.01, *** p < 0.001. n = 25 (control), 13 (Foxp1 D1 ), 14 (Foxp2 D1 ), and 16 (Foxp1/2 D1 ) for (A); n = 15, 13, 18, and 12 respectively for (B); and n = 14, 11, 12, and 10 respectively for (C) and (D). All graphs are displayed as mean ± SEM.

    Journal: Cell reports

    Article Title: Compensation between FOXP transcription factors maintains proper striatal function

    doi: 10.1016/j.celrep.2024.114257

    Figure Lengend Snippet: (A) Foxp1/2 D1 mice show motor learning deficit as assessed by latency to fall using the rotarod paradigm. (B) Nest-building quality was assessed after single housing for 24 h with Foxp1 D1 showing impairment, and this is amplified in Foxp1/2 D1 . (C and D) AAV-mediated re-expression of Foxp1 restored measures to baseline in rotarod (C) and nest building (D). (A and B) Behavior performed in control, Foxp1 D1 , Foxp2 D1 , and Foxp1/2 D1 . (C and D) Performed in control or Foxp1/2 D1 mice with either control AAV9-hSYN1-eGFP or pAAV-hSYN-Foxp1-T2A-eGFP construct. (A–D) Two-way ANOVA with Tukey’s post hoc analysis used to determine significance. * p < 0.05, ** p < 0.01, *** p < 0.001. n = 25 (control), 13 (Foxp1 D1 ), 14 (Foxp2 D1 ), and 16 (Foxp1/2 D1 ) for (A); n = 15, 13, 18, and 12 respectively for (B); and n = 14, 11, 12, and 10 respectively for (C) and (D). All graphs are displayed as mean ± SEM.

    Article Snippet: Mouse: STOCK Foxp1 tm1.1Pwt /J , Jackson Laboratory , Strain#: 017699; RRID: IMSR_JAX:017699.

    Techniques: Amplification, Expressing, Control, Construct

    Journal: Cell reports

    Article Title: Compensation between FOXP transcription factors maintains proper striatal function

    doi: 10.1016/j.celrep.2024.114257

    Figure Lengend Snippet:

    Article Snippet: Mouse: STOCK Foxp1 tm1.1Pwt /J , Jackson Laboratory , Strain#: 017699; RRID: IMSR_JAX:017699.

    Techniques: Virus, Optogenetics, Recombinant, RNAscope, Isolation, SYBR Green Assay, Multiplex Assay, Transgenic Assay, Software